Bio Target Search

{
  "other_matches": [
    {
      "description": "BRCA1 pseudogene 1",
      "ensembl_id": "ENSG00000267595",
      "symbol": "BRCA1P1"
    },
    {
      "description": "BRCA1 interacting DNA helicase 1",
      "ensembl_id": "ENSG00000136492",
      "symbol": "BRIP1"
    },
    {
      "description": "BRCA1 associated deubiquitinase 1",
      "ensembl_id": "ENSG00000163930",
      "symbol": "BAP1"
    },
    {
      "description": "BRCA1 associated RING domain 1",
      "ensembl_id": "ENSG00000138376",
      "symbol": "BARD1"
    }
  ],
  "query": "BRCA1",
  "source": "Open Targets Platform",
  "top_match": {
    "associated_disease_count": 1324,
    "biotype": "protein_coding",
    "ensembl_id": "ENSG00000012048",
    "function": "E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microt…",
    "location": {
      "chromosome": "17",
      "end": 43170245,
      "start": 43044292,
      "strand": "NEGATIVE"
    },
    "name": "BRCA1 DNA repair associated",
    "symbol": "BRCA1",
    "top_diseases": [
      {
        "association_score": 0.844,
        "disease": "breast cancer",
        "efo_id": "MONDO_0007254"
      },
      {
        "association_score": 0.828,
        "disease": "hereditary breast ovarian cancer syndrome",
        "efo_id": "MONDO_0003582"
      },
      {
        "association_score": 0.817,
        "disease": "Fanconi anemia, complementation group S",
        "efo_id": "MONDO_0054748"
      },
      {
        "association_score": 0.811,
        "disease": "ovarian cancer",
        "efo_id": "MONDO_0008170"
      },
      {
        "association_score": 0.8,
        "disease": "breast neoplasm",
        "efo_id": "MONDO_0021100"
      },
      {
        "association_score": 0.799,
        "disease": "breast-ovarian cancer, familial, susceptibility to, 1",
        "efo_id": "MONDO_0011450"
      },
      {
        "association_score": 0.788,
        "disease": "ovarian neoplasm",
        "efo_id": "MONDO_0021068"
      },
      {
        "association_score": 0.779,
        "disease": "cancer",
        "efo_id": "MONDO_0004992"
      }
    ],
    "tractability_by_modality": {
      "AB": [
        "GO CC high conf"
      ],
      "PR": [
        "UniProt Ubiquitination",
        "Database Ubiquitination",
        "Small Molecule Binder"
      ],
      "SM": [
        "Druggable Family"
      ]
    }
  },
  "url": "https://platform.opentargets.org/target/ENSG00000012048"
}

# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://saylorinnovations.com/api/bio/target-search?q=BRCA1'

# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://saylorinnovations.com/api/bio/target-search?q=BRCA1' \
  | grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decode

// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";

// Pays at most $0.01 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.01" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);

// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.01 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fsaylorinnovations.com%2Fapi%2Fbio%2Ftarget-search
const res = await pay("https://saylorinnovations.com/api/bio/target-search?q=BRCA1");
console.log(res.status, await res.text());

# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client

# Pays at most $0.01 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.01"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))

with x402_requests(client) as session:
    res = session.get("https://saylorinnovations.com/api/bio/target-search?q=BRCA1")
    print(res.status_code, res.text)