75trust / 100

Bio Variants

by Saylor Innovations Bioinformatic in Other

x402 APIPassing, checked 1 h ago

ClinVar variants for a gene filtered by clinical significance - counts and latest records

GET
https://saylorinnovations.com/api/bio/variants
Price
$0.01
per call in USDC
Uptime
100%
last 30 days
Response time
563 ms
2.8 s slowest 5%
Last check
Passed
1 h ago, next any minute now

Run a free test callHow to call it

Reliability

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Status and outage history · Atom feed

How to call it

GET https://saylorinnovations.com/api/bio/variants

Each call costs $0.01 in USDC on Base, paid with the request over x402.

Run a free test callOne unpaid request, the way an agent sends it. You see the payment challenge it gets back. Nothing is charged.

Example request

From the listing.

GET https://saylorinnovations.com/api/bio/variants?gene=BRCA1&significance=pathogenic

Parameters

ParameterTypeRequiredDescription
genestringNogene symbol (query)
significancestringNopathogenic | likely_pathogenic | uncertain | benign | likely_benign | conflicting (query, optional)

Example response

The provider's example. We can't check it without paying.

{
  "found": true,
  "gene": "BRCA1",
  "significance": "pathogenic",
  "total_in_clinvar": 4381,
  "variants": [
    {
      "accession": "VCV000055601",
      "classification": "Pathogenic",
      "review_stars": 3,
      "title": "NM_007294.4(BRCA1):c.5266dup (p.Gln1756fs)"
    }
  ]
}

Call it from code

The curl command shows the payment challenge. The JavaScript and Python versions pay and call, and never pay more than $0.01.

curl: see the payment challenge
# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://saylorinnovations.com/api/bio/variants?gene=BRCA1&significance=pathogenic'

# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://saylorinnovations.com/api/bio/variants?gene=BRCA1&significance=pathogenic' \
  | grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decode
JavaScript: pay and call
// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";

// Pays at most $0.01 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.01" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);

// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.01 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fsaylorinnovations.com%2Fapi%2Fbio%2Fvariants
const res = await pay("https://saylorinnovations.com/api/bio/variants?gene=BRCA1&significance=pathogenic");
console.log(res.status, await res.text());
Python: pay and call
# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client

# Pays at most $0.01 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.01"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))

with x402_requests(client) as session:
    res = session.get("https://saylorinnovations.com/api/bio/variants?gene=BRCA1&significance=pathogenic")
    print(res.status_code, res.text)

Security scan

No findings

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Recent checks

WhenResultHTTPTimePrice
1 h agoPassed402706 ms$0.01
5 h agoPassed402669 ms$0.01
10 h agoPassed402916 ms$0.01
14 h agoPassed4021.6 s$0.01
18 h agoPassed402329 ms$0.01
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22 h agoPassed402702 ms$0.01
25 h agoPassed402447 ms$0.01
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2 days agoPassed4022.8 s$0.01