62trust / 100

Calc Hfa Icos Vegf

x402 APIFailing, checked 6 h ago

Lyon 2020 HFA-ICOS baseline CV risk before VEGF inhibitors or VEGF TKIs. Very high if heart failure/cardiomyopathy or arterial vascular disease. High if venous thrombosis, LVEF <50%, QTc >=480 ms, age >=75, hypertension, prior anthracycline, or >=5 medium points. Medium if 2-4 medium points. Guide <2% / 2-9% / 10-19% / >=20%. Not a device or treatment order.

POST

https://api.magentlab.com/api/calc/hfa_icos_vegf

Price: $0.007; per call in USDC
Uptime: 91.4%; last 30 days
Response time: 338 ms; 683 ms slowest 5%
Last check: Failed; 6 h ago, next any minute now

Run a free test call How to call it

Reliability

All checks passedSome failedAll failedNot checked

Latest check failed 6 h ago: Timed out

Status and outage history · Atom feed · Watch with other listings

How to call it

POST https://api.magentlab.com/api/calc/hfa_icos_vegf

Each call costs $0.007 in USDC on Base, paid with the request over x402.

Run a free test callOne unpaid request, the way an agent sends it. You see the payment challenge it gets back. Nothing is charged.

Example request

From the listing.

POST https://api.magentlab.com/api/calc/hfa_icos_vegf
content-type: application/json

{
  "items": [
    {
      "age_years": 50,
      "arrhythmia": false,
      "arterial_vascular_disease": false,
      "ckd": false,
      "current_or_significant_smoker": false,
      "diabetes": false,
      "elevated_bnp": false,
      "elevated_troponin": false,
      "heart_failure_or_cardiomyopathy": false,
      "hyperlipidemia": false,
      "hypertension": false,
      "lvef_percent": 60,
      "obesity": false,
      "prior_anthracycline": false,
      "prior_left_chest_or_mediastinal_rt": false,
      "proteinuria": false,
      "qtc_ms": 400,
      "sex": "female",
      "venous_thrombosis": false
    },
    {
      "age_years": 50,
      "arrhythmia": false,
      "arterial_vascular_disease": false,
      "ckd": false,
      "current_or_significant_smoker": false,
      "diabetes": false,
      "elevated_bnp": false,
      "elevated_troponin": false,
      "heart_failure_or_cardiomyopathy": false,
      "hyperlipidemia": false,
      "hypertension": false,
      "lvef_percent": 60,
      "obesity": false,
      "prior_anthracycline": false,
      "prior_left_chest_or_mediastinal_rt": false,
      "proteinuria": false,
      "qtc_ms": 400,
      "sex": "female",
      "venous_thrombosis": false
    }
  ]
}

Parameters

Parameter	Type	Required	Description
`items`	array of object	Yes

Example response

The provider's example. We can't check it without paying. Shortened for display.

Example response, 294 lines

{
  "count": 2,
  "items": [
    {
      "age_years": 50,
      "cardiotoxicity_guide": "<2%",
      "citation": {
        "authors": "Lyon AR, Dent S, Stanway S, et al.",
        "doi": "10.1002/ejhf.1920",
        "id": "lyon-2020",
        "pmid": "32458582",
        "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
        "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
      },
      "components": [
        {
          "factor": "heart_failure_or_cardiomyopathy",
          "points": 0,
          "present": false,
          "tier": "very_high"
        },
        {
          "factor": "arterial_vascular_disease",
          "points": 0,
          "present": false,
          "tier": "very_high"
        },
        {
          "factor": "venous_thrombosis",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "lvef_lt_50",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "qtc_ge_480",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "age_ge_75",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "hypertension",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "prior_anthracycline",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "lvef_50_to_54",
          "points": 0,
          "present": false,
          "tier": "medium_2"
        },
        {
          "factor": "borderline_qtc",
          "points": 0,
          "present": false,
          "tier": "medium_2"
        },
        {
          "factor": "arrhythmia",
          "points": 0,
          "present": false,
          "tier": "medium_2"
        },
        {
          "factor": "elevated_troponin",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "elevated_bnp",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "age_65_to_74",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "diabetes",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "hyperlipidemia",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "ckd",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "proteinuria",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "prior_left_chest_or_mediastinal_rt",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "current_or_significant_smoker",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "formula": "hfa_icos_vegf",
      "formula_expression": "HFA-ICOS VEGF-inhibitor class (Lyon 2020): very_high if any very-high factor; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low. medium_points = Medium 2 + Medium 1 only. Very high: heart_failure_or_cardiomyopathy, arterial_vascular_disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD). High: venous_thrombosis, lvef_percent<50, qtc_ms>=480, age_years>=75, hypertension, prior_anthracycline. Medium 2: lvef 50-54, male 450<=qtc<480, female 460<=qtc<480, arrhythmia (AF/flutter/VT/VF). Medium 1: elevated_troponin, elevated_bnp, age 65-74, diabetes, hyperlipidemia, ckd, proteinuria, prior_left_chest_or_mediastinal_rt, current_or_significant_smoker, obesity. Age exclusive (>=75 High; 65-74 Medium 1; <65 none). LVEF exclusive (<50 High; 50-54 Medium 2; >=55 none). QTc exclusive (>=480 High; else sex-specific Medium 2). cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%",
      "high_factor": false,
      "lvef_percent": 60,
      "medium_points": 0,
      "qtc_ms": 400,
      "risk_level": "low",
      "sex": "female",
      "very_high_factor": false
    },
    {
      "age_years": 50,
      "cardiotoxicity_guide": "<2%",
      "citation": {
        "authors": "Lyon AR, Dent S, Stanway S, et al.",
        "doi": "10.1002/ejhf.1920",
        "id": "lyon-2020",
        "pmid": "32458582",
        "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
        "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
      },
      "components": [
        {
          "factor": "heart_failure_or_cardiomyopathy",
          "points": 0,
          "present": false,
          "tier": "very_high"
        },
        {
          "factor": "arterial_vascular_disease",
          "points": 0,
          "present": false,
          "tier": "very_high"
        },
        {
          "factor": "venous_thrombosis",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "lvef_lt_50",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "qtc_ge_480",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "age_ge_75",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "hypertension",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "prior_anthracycline",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "lvef_50_to_54",
          "points": 0,
          "present": false,
          "tier": "medium_2"
        },
        {
          "factor": "borderline_qtc",
          "points": 0,
          "present": false,
          "tier": "medium_2"
        },
        {
          "factor": "arrhythmia",
          "points": 0,
          "present": false,
          "tier": "medium_2"
        },
        {
          "factor": "elevated_troponin",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "elevated_bnp",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "age_65_to_74",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "diabetes",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "hyperlipidemia",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "ckd",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "proteinuria",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "prior_left_chest_or_mediastinal_rt",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        },
        {
          "factor": "current_or_significant_smoker",
          "points": 0,
          "present": false,
          "tier": "medium_1"
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "formula": "hfa_icos_vegf",
      "formula_expression": "HFA-ICOS VEGF-inhibitor class (Lyon 2020): very_high if any very-high factor; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low. medium_points = Medium 2 + Medium 1 only. Very high: heart_failure_or_cardiomyopathy, arterial_vascular_disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD). High: venous_thrombosis, lvef_percent<50, qtc_ms>=480, age_years>=75, hypertension, prior_anthracycline. Medium 2: lvef 50-54, male 450<=qtc<480, female 460<=qtc<480, arrhythmia (AF/flutter/VT/VF). Medium 1: elevated_troponin, elevated_bnp, age 65-74, diabetes, hyperlipidemia, ckd, proteinuria, prior_left_chest_or_mediastinal_rt, current_or_significant_smoker, obesity. Age exclusive (>=75 High; 65-74 Medium 1; <65 none). LVEF exclusive (<50 High; 50-54 Medium 2; >=55 none). QTc exclusive (>=480 High; else sex-specific Medium 2). cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%",
      "high_factor": false,
      "lvef_percent": 60,
      "medium_points": 0,
      "qtc_ms": 400,
      "risk_level": "low",
      "sex": "female",
      "very_high_factor": false
    }
  ],
  "path": "/api/calc/hfa_icos_vegf"
}

Call it from code

The curl command shows the payment challenge. The JavaScript and Python versions pay and call, and never pay more than $0.007.

curl: see the payment challenge

# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i -X POST 'https://api.magentlab.com/api/calc/hfa_icos_vegf' \
  -H 'content-type: application/json' \
  --data-raw '{"items":[{"age_years":50,"arrhythmia":false,"arterial_vascular_disease":false,"ckd":false,"current_or_significant_smoker":false,"diabetes":false,"elevated_bnp":false,"elevated_troponin":false,"heart_failure_or_cardiomyopathy":false,"hyperlipidemia":false,"hypertension":false,"lvef_percent":60,"obesity":false,"prior_anthracycline":false,"prior_left_chest_or_mediastinal_rt":false,"proteinuria":false,"qtc_ms":400,"sex":"female","venous_thrombosis":false},{"age_years":50,"arrhythmia":false,"arterial_vascular_disease":false,"ckd":false,"current_or_significant_smoker":false,"diabetes":false,"elevated_bnp":false,"elevated_troponin":false,"heart_failure_or_cardiomyopathy":false,"hyperlipidemia":false,"hypertension":false,"lvef_percent":60,"obesity":false,"prior_anthracycline":false,"prior_left_chest_or_mediastinal_rt":false,"proteinuria":false,"qtc_ms":400,"sex":"female","venous_thrombosis":false}]}'

# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - -X POST 'https://api.magentlab.com/api/calc/hfa_icos_vegf' \
  -H 'content-type: application/json' \
  --data-raw '{"items":[{"age_years":50,"arrhythmia":false,"arterial_vascular_disease":false,"ckd":false,"current_or_significant_smoker":false,"diabetes":false,"elevated_bnp":false,"elevated_troponin":false,"heart_failure_or_cardiomyopathy":false,"hyperlipidemia":false,"hypertension":false,"lvef_percent":60,"obesity":false,"prior_anthracycline":false,"prior_left_chest_or_mediastinal_rt":false,"proteinuria":false,"qtc_ms":400,"sex":"female","venous_thrombosis":false},{"age_years":50,"arrhythmia":false,"arterial_vascular_disease":false,"ckd":false,"current_or_significant_smoker":false,"diabetes":false,"elevated_bnp":false,"elevated_troponin":false,"heart_failure_or_cardiomyopathy":false,"hyperlipidemia":false,"hypertension":false,"lvef_percent":60,"obesity":false,"prior_anthracycline":false,"prior_left_chest_or_mediastinal_rt":false,"proteinuria":false,"qtc_ms":400,"sex":"female","venous_thrombosis":false}]}' \
  | grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decode

JavaScript: pay and call

// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";

// Pays at most $0.007 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.007" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);

// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.007 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fapi.magentlab.com%2Fapi%2Fcalc%2Fhfa_icos_vegf&method=POST
const res = await pay("https://api.magentlab.com/api/calc/hfa_icos_vegf", {
  method: "POST",
  headers: { "content-type": "application/json" },
  body: JSON.stringify({
    "items": [
      {
        "age_years": 50,
        "arrhythmia": false,
        "arterial_vascular_disease": false,
        "ckd": false,
        "current_or_significant_smoker": false,
        "diabetes": false,
        "elevated_bnp": false,
        "elevated_troponin": false,
        "heart_failure_or_cardiomyopathy": false,
        "hyperlipidemia": false,
        "hypertension": false,
        "lvef_percent": 60,
        "obesity": false,
        "prior_anthracycline": false,
        "prior_left_chest_or_mediastinal_rt": false,
        "proteinuria": false,
        "qtc_ms": 400,
        "sex": "female",
        "venous_thrombosis": false
      },
      {
        "age_years": 50,
        "arrhythmia": false,
        "arterial_vascular_disease": false,
        "ckd": false,
        "current_or_significant_smoker": false,
        "diabetes": false,
        "elevated_bnp": false,
        "elevated_troponin": false,
        "heart_failure_or_cardiomyopathy": false,
        "hyperlipidemia": false,
        "hypertension": false,
        "lvef_percent": 60,
        "obesity": false,
        "prior_anthracycline": false,
        "prior_left_chest_or_mediastinal_rt": false,
        "proteinuria": false,
        "qtc_ms": 400,
        "sex": "female",
        "venous_thrombosis": false
      }
    ]
  }),
});
console.log(res.status, await res.text());

Python: pay and call

# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client

# Pays at most $0.007 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.007"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))

with x402_requests(client) as session:
    res = session.post(
        "https://api.magentlab.com/api/calc/hfa_icos_vegf",
        json={
            "items": [
                {
                    "age_years": 50,
                    "arrhythmia": False,
                    "arterial_vascular_disease": False,
                    "ckd": False,
                    "current_or_significant_smoker": False,
                    "diabetes": False,
                    "elevated_bnp": False,
                    "elevated_troponin": False,
                    "heart_failure_or_cardiomyopathy": False,
                    "hyperlipidemia": False,
                    "hypertension": False,
                    "lvef_percent": 60,
                    "obesity": False,
                    "prior_anthracycline": False,
                    "prior_left_chest_or_mediastinal_rt": False,
                    "proteinuria": False,
                    "qtc_ms": 400,
                    "sex": "female",
                    "venous_thrombosis": False,
                },
                {
                    "age_years": 50,
                    "arrhythmia": False,
                    "arterial_vascular_disease": False,
                    "ckd": False,
                    "current_or_significant_smoker": False,
                    "diabetes": False,
                    "elevated_bnp": False,
                    "elevated_troponin": False,
                    "heart_failure_or_cardiomyopathy": False,
                    "hyperlipidemia": False,
                    "hypertension": False,
                    "lvef_percent": 60,
                    "obesity": False,
                    "prior_anthracycline": False,
                    "prior_left_chest_or_mediastinal_rt": False,
                    "proteinuria": False,
                    "qtc_ms": 400,
                    "sex": "female",
                    "venous_thrombosis": False,
                },
            ],
        },
    )
    print(res.status_code, res.text)

Security scan

1 finding

Charges more than its listed price in payment
Listed at $0.005, charges $0.007

Recent checks

When	Result	HTTP	Time	Price
6 h ago	Timed out	-	-	-
10 h ago	Timed out	-	-	-
15 h ago	Timed out	-	-	-
20 h ago	Passed	402	360 ms	$0.007
25 h ago	Passed	402	310 ms	$0.007

Show 10 older checks

30 h ago	Passed	402	294 ms	$0.007
34 h ago	Passed	402	353 ms	$0.007
39 h ago	Passed	402	383 ms	$0.007
43 h ago	Passed	402	173 ms	$0.007
2 days ago	Passed	402	319 ms	$0.007
2 days ago	Passed	402	453 ms	$0.007
2 days ago	Passed	402	327 ms	$0.007
3 days ago	Passed	402	452 ms	$0.007
3 days ago	Passed	402	642 ms	$0.007
3 days ago	Passed	402	683 ms	$0.007

History

11 Oct 2026	Price changed from $0.005 to $0.007

Trust score 62/ 100

Availability (30-day uptime)		27 / 30
Valid x402 challenge		15 / 15
Response time		7 / 10
Real paying agents (30 days)		3 / 15
Charges what it lists		0 / 10
Security scan		10 / 10
Verified owner		0 / 10

How the score works

Payment terms

Price: $0.007 per call
Listed at: $0.005 (charges more)
Token: USDC
Networks: Base
Pays to: 0x836B…9Ee2

Real usage

Paying agents: 1 in 30 days
Paid calls: 3 in 30 days
Last paid call: 5 days ago

Source: x402 Bazaar settlement data.

Is this your service?

Verify ownership to get the badge and 10 more trust points. Featured placement needs it too.

Verify ownership

Changed something? Check it again now and see what agents get.

Show the score

A badge for your README or docs. It updates with every check and links here.

Trust score

[![ToolVet trust score](https://toolvet.app/badge/calc-hfa-icos-vegf.svg)](https://toolvet.app/s/calc-hfa-icos-vegf)