73trust / 100

Calc Icc Pmf

by magent in Other

x402 APIFailing, checked 27 min ago

ICC 2022 prefibrotic and overt PMF (Arber 2022). Diagnosed iff 3 majors and ≥1 minor. Majors: megakaryocyte morphology, not another myeloid neoplasm, JAK2/CALR/MPL or other clone or no reactive fibrosis. Minors: anemia not from comorbidity, WBC ≥11e9/L, splenomegaly, LDH above ULN; leukoerythroblastosis counts only in overt PMF. Not DIPSS, MIPSS70, WHO 5th, or post-PV/post-ET MF. magent does not read fibrosis grade or sequence drivers. Not a diagnosis or medical device.

GET
https://api.magentlab.com/api/calc/icc_pmf
Price
$0.005
per call in USDC
Uptime
92.3%
last 30 days
Response time
219 ms
593 ms slowest 5%
Last check
Failed
27 min ago, next in 6 h

Run a free test callHow to call it

Reliability

All checks passedSome failedAll failedNot checked

Latest check failed 27 min ago: Timed out

Status and outage history · Atom feed · Watch with other listings

How to call it

GET https://api.magentlab.com/api/calc/icc_pmf

Each call costs $0.005 in USDC on Base, paid with the request over x402.

Run a free test callOne unpaid request, the way an agent sends it. You see the payment challenge it gets back. Nothing is charged.

Example request

From the listing.

GET https://api.magentlab.com/api/calc/icc_pmf?anemia_not_comorbid=true&clonal_or_no_reactive=true&ldh_above_uln=false&leukocytosis_ge_11=false&leukoerythroblastosis=false&megakaryocyte_morphology=true&not_other_myeloid=true&phenotype=pre&splenomegaly=false

Parameters

ParameterTypeRequiredDescription
anemia_not_comorbidbooleanYesAnemia not attributed to a comorbid condition, as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay hemoglobin.
clonal_or_no_reactivebooleanYesJAK2, CALR, or MPL mutation, or another clonal marker, or absence of reactive bone-marrow fibrosis, as assigned by the caller (Arber 2022 ICC PMF major). true or false. magent does not sequence.
ldh_above_ulnbooleanYesLDH above the institutional upper limit of normal as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay LDH.
leukocytosis_ge_11booleanYesLeukocytosis ≥11 × 10^9/L as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not assay WBC.
leukoerythroblastosisbooleanYesLeukoerythroblastosis as assigned by the caller (Arber 2022 ICC overt-PMF minor). Counts toward minor_count only when phenotype is overt; echoed but not counted when phenotype is pre. true or false. magent does not read a smear.
megakaryocyte_morphologybooleanYesMegakaryocytic proliferation and atypia for the chosen phenotype, as assigned by the caller (Arber 2022 ICC PMF major). For pre: without reticulin fibrosis grade >1, with increased age-adjusted cellularity, granulocytic proliferation, and often decreased erythropoiesis. For overt: accompanied by re…
not_other_myeloidbooleanYesDoes not meet ICC/WHO criteria for BCR::ABL1-positive CML, PV, ET, MDS, or another defined myeloid neoplasm, as assigned by the caller (Arber 2022 ICC PMF major). true or false. magent does not diagnose those neoplasms.
phenotypestringYespre (prefibrotic/early PMF) or overt (overt fibrotic PMF) as assigned by the caller (Arber 2022 ICC). Required. magent does not assign phenotype from a biopsy. One of: pre, overt.
splenomegalybooleanYesPalpable splenomegaly as assigned by the caller (Arber 2022 ICC PMF minor). true or false. magent does not examine the spleen.

Example response

The provider's example. We can't check it without paying.

Example response, 67 lines
{
  "anemia_not_comorbid": true,
  "citation": {
    "authors": "Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Bennett JM, de la Fuente J, et al.",
    "doi": "10.1182/blood.2022015850",
    "id": "arber-2022",
    "pmid": "35767897",
    "source": "Blood. 2022;140(11):1200-1228",
    "title": "International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data"
  },
  "clonal_or_no_reactive": true,
  "criteria": [
    {
      "factor": "megakaryocyte_morphology",
      "met": true
    },
    {
      "factor": "not_other_myeloid",
      "met": true
    },
    {
      "factor": "clonal_or_no_reactive",
      "met": true
    },
    {
      "factor": "anemia_not_comorbid",
      "met": true
    },
    {
      "factor": "leukocytosis_ge_11",
      "met": false
    },
    {
      "factor": "splenomegaly",
      "met": false
    },
    {
      "factor": "ldh_above_uln",
      "met": false
    },
    {
      "factor": "leukoerythroblastosis",
      "met": false
    },
    {
      "factor": "three_majors",
      "met": true
    },
    {
      "factor": "minor_count_ge_1",
      "met": true
    }
  ],
  "diagnosed": true,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "formula": "icc_pmf",
  "formula_expression": "diagnosed iff three majors and minor_count ≥ 1; majors are megakaryocyte_morphology, not_other_myeloid, and clonal_or_no_reactive; minor_count is anemia_not_comorbid + leukocytosis_ge_11 + splenomegaly + ldh_above_uln + leukoerythroblastosis only when phenotype is overt (Arber 2022 ICC pre-PMF and overt PMF). Not DIPSS. Not WHO 5th. Not post-PV/post-ET myelofibrosis",
  "ldh_above_uln": false,
  "leukocytosis_ge_11": false,
  "leukoerythroblastosis": false,
  "major_count": 3,
  "megakaryocyte_morphology": true,
  "minor_count": 1,
  "not_other_myeloid": true,
  "phenotype": "pre",
  "splenomegaly": false
}

Call it from code

The curl command shows the payment challenge. The JavaScript and Python versions pay and call, and never pay more than $0.005.

curl: see the payment challenge
# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://api.magentlab.com/api/calc/icc_pmf?anemia_not_comorbid=true&clonal_or_no_reactive=true&ldh_above_uln=false&leukocytosis_ge_11=false&leukoerythroblastosis=false&megakaryocyte_morphology=true&not_other_myeloid=true&phenotype=pre&splenomegaly=false'

# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://api.magentlab.com/api/calc/icc_pmf?anemia_not_comorbid=true&clonal_or_no_reactive=true&ldh_above_uln=false&leukocytosis_ge_11=false&leukoerythroblastosis=false&megakaryocyte_morphology=true&not_other_myeloid=true&phenotype=pre&splenomegaly=false' \
  | grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decode
JavaScript: pay and call
// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";

// Pays at most $0.005 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.005" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);

// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.005 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fapi.magentlab.com%2Fapi%2Fcalc%2Ficc_pmf
const res = await pay("https://api.magentlab.com/api/calc/icc_pmf?anemia_not_comorbid=true&clonal_or_no_reactive=true&ldh_above_uln=false&leukocytosis_ge_11=false&leukoerythroblastosis=false&megakaryocyte_morphology=true&not_other_myeloid=true&phenotype=pre&splenomegaly=false");
console.log(res.status, await res.text());
Python: pay and call
# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client

# Pays at most $0.005 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.005"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))

with x402_requests(client) as session:
    res = session.get("https://api.magentlab.com/api/calc/icc_pmf?anemia_not_comorbid=true&clonal_or_no_reactive=true&ldh_above_uln=false&leukocytosis_ge_11=false&leukoerythroblastosis=false&megakaryocyte_morphology=true&not_other_myeloid=true&phenotype=pre&splenomegaly=false")
    print(res.status_code, res.text)

Security scan

No findings

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Recent checks

WhenResultHTTPTimePrice
27 min agoTimed out---
12 h agoPassed402219 ms$0.005
22 h agoPassed402271 ms$0.005
32 h agoPassed402145 ms$0.005
42 h agoPassed402372 ms$0.005
Show 8 older checks
2 days agoPassed402238 ms$0.005
3 days agoPassed402159 ms$0.005
3 days agoPassed402309 ms$0.005
3 days agoPassed402139 ms$0.005
4 days agoPassed402292 ms$0.005
4 days agoPassed402593 ms$0.005
5 days agoPassed402138 ms$0.005
5 days agoPassed402169 ms$0.005