Calc Icc Sm
by magent in Other
ICC 2022 systemic mastocytosis (Arber 2022). Met when major infiltrates (≥15 tryptase- and/or CD117-positive MCs in aggregates in BM or extracutaneous organ) alone, or ≥3 minors. Minors: >25% spindle or atypical immature morphology, KIT D816V or other activating KIT mutation, CD25/CD2/CD30, tryptase >20 ng/mL (not counted in SM-AMN). Not a diagnosis. Not Valent 2016 WHO SM. Not WHO 5th/Khoury. Not cutaneous mastocytosis only. magent does not read a biopsy or assay tryptase.
https://api.magentlab.com/api/calc/icc_sm- Price
- $0.005
- per call in USDC
- Uptime
- 100%
- last 30 days
- Response time
- 152 ms
- 359 ms slowest 5%
- Last check
- Passed
- 3 h ago, next in 3 h
Reliability
Status and outage history · Atom feed · Watch with other listings
How to call it
GET https://api.magentlab.com/api/calc/icc_sm
Each call costs $0.005 in USDC on Base, paid with the request over x402.
Run a free test callOne unpaid request, the way an agent sends it. You see the payment challenge it gets back. Nothing is charged.
Example request
From the listing.
GET https://api.magentlab.com/api/calc/icc_sm?associated_myeloid_neoplasm=false&atypical_or_spindle=false&cd2_cd25_or_cd30=false&kit_activating=false&major_infiltrates=true&tryptase_gt_20=falseParameters
| Parameter | Type | Required | Description |
|---|---|---|---|
associated_myeloid_neoplasm | boolean | Yes | Associated myeloid neoplasm (ICC SM-AMN) as assigned by the caller. When true, tryptase_gt_20 does not count as a minor. true or false. magent does not diagnose a myeloid neoplasm. |
atypical_or_spindle | boolean | Yes | >25% spindle-shaped or atypical immature morphology in bone marrow or extracutaneous sections, as assigned by the caller (Arber 2022 ICC SM minor). true or false. magent does not read slides. |
cd2_cd25_or_cd30 | boolean | Yes | Mast cells express CD25, CD2, and/or CD30 in addition to mast-cell markers, as assigned by the caller (Arber 2022 ICC SM minor; ICC adds CD30). true or false. magent does not phenotype mast cells. |
kit_activating | boolean | Yes | KIT D816V or other activating KIT mutation in bone marrow, blood, or an extracutaneous organ, as assigned by the caller (Arber 2022 ICC SM minor; not codon-816-only). true or false. magent does not sequence KIT. |
major_infiltrates | boolean | Yes | Multifocal dense infiltrates of tryptase- and/or CD117-positive mast cells (≥15 MCs in aggregates) in bone marrow or another extracutaneous organ, as assigned by the caller (Arber 2022 ICC SM major). true or false. magent does not read a biopsy. |
tryptase_gt_20 | boolean | Yes | Serum tryptase persistently >20 ng/mL as assigned by the caller (Arber 2022 ICC SM minor). Does not count when associated_myeloid_neoplasm is true (SM-AMN). true or false. magent does not assay tryptase. |
Example response
The provider's example. We can't check it without paying.
Example response, 53 lines
{
"associated_myeloid_neoplasm": false,
"atypical_or_spindle": false,
"cd2_cd25_or_cd30": false,
"citation": {
"authors": "Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Kvasnicka HM, Wang SA, Bagg A, Barbui T, Bennett JM, de la Fuente J, et al.",
"doi": "10.1182/blood.2022015850",
"id": "arber-2022",
"pmid": "35767897",
"source": "Blood. 2022;140(11):1200-1228",
"title": "International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data"
},
"criteria": [
{
"factor": "major",
"met": true
},
{
"factor": "atypical_or_spindle",
"met": false
},
{
"factor": "kit_activating",
"met": false
},
{
"factor": "cd2_cd25_or_cd30",
"met": false
},
{
"factor": "tryptase_counts",
"met": false
},
{
"factor": "associated_myeloid_neoplasm",
"met": false
},
{
"factor": "minor_count_ge_3",
"met": false
}
],
"diagnosed": true,
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"formula": "icc_sm",
"formula_expression": "diagnosed iff major_infiltrates or minor_count ≥ 3; minor_count counts atypical_or_spindle, kit_activating, cd2_cd25_or_cd30, and tryptase_gt_20 only when associated_myeloid_neoplasm is false (Arber 2022 ICC SM). Not a diagnosis. Not Valent 2016 WHO SM. Not cutaneous mastocytosis only",
"kit_activating": false,
"major": true,
"major_infiltrates": true,
"minor_count": 0,
"tryptase_counts": false,
"tryptase_gt_20": false
}Call it from code
The curl command shows the payment challenge. The JavaScript and Python versions pay and call, and never pay more than $0.005.
curl: see the payment challenge
# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://api.magentlab.com/api/calc/icc_sm?associated_myeloid_neoplasm=false&atypical_or_spindle=false&cd2_cd25_or_cd30=false&kit_activating=false&major_infiltrates=true&tryptase_gt_20=false'
# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://api.magentlab.com/api/calc/icc_sm?associated_myeloid_neoplasm=false&atypical_or_spindle=false&cd2_cd25_or_cd30=false&kit_activating=false&major_infiltrates=true&tryptase_gt_20=false' \
| grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decodeJavaScript: pay and call
// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";
// Pays at most $0.005 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.005" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);
// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.005 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fapi.magentlab.com%2Fapi%2Fcalc%2Ficc_sm
const res = await pay("https://api.magentlab.com/api/calc/icc_sm?associated_myeloid_neoplasm=false&atypical_or_spindle=false&cd2_cd25_or_cd30=false&kit_activating=false&major_infiltrates=true&tryptase_gt_20=false");
console.log(res.status, await res.text());Python: pay and call
# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client
# Pays at most $0.005 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.005"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))
with x402_requests(client) as session:
res = session.get("https://api.magentlab.com/api/calc/icc_sm?associated_myeloid_neoplasm=false&atypical_or_spindle=false&cd2_cd25_or_cd30=false&kit_activating=false&major_infiltrates=true&tryptase_gt_20=false")
print(res.status_code, res.text)Security scan
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Recent checks
| When | Result | HTTP | Time | Price |
|---|---|---|---|---|
| 3 h ago | Passed | 402 | 255 ms | $0.005 |
| 13 h ago | Passed | 402 | 152 ms | $0.005 |
| 23 h ago | Passed | 402 | 161 ms | $0.005 |
| 33 h ago | Passed | 402 | 275 ms | $0.005 |
| 43 h ago | Passed | 402 | 185 ms | $0.005 |
Show 6 older checks
| 2 days ago | Passed | 402 | 359 ms | $0.005 |
| 3 days ago | Passed | 402 | 146 ms | $0.005 |
| 3 days ago | Passed | 402 | 145 ms | $0.005 |
| 3 days ago | Passed | 402 | 137 ms | $0.005 |
| 4 days ago | Passed | 402 | 152 ms | $0.005 |
| 4 days ago | Passed | 402 | 136 ms | $0.005 |