Calc Mipss70
by magent in Other
Guglielmelli 2018 MIPSS70 for transplant-age PMF: Hb <10 g/dL (1), leukocytes >25×10^9/L (2), platelets <100×10^9/L (2), blasts ≥2% (1), fibrosis ≥2 (1), symptoms (1), no type 1/like CALR (1), HMR category (1), ≥2 HMR (2); max 12. Low 0–1, intermediate 2–4, high ≥5. Italian-cohort median (5-year) OS 27.7 y (95%), 7.1 y (70%), 2.3 y (29%). Not MIPSS70-plus or version 2.0. magent does not sequence or grade marrow.
https://api.magentlab.com/api/calc/mipss70- Price
- $0.005
- per call in USDC
- Uptime
- 92.3%
- last 30 days
- Response time
- 146 ms
- 519 ms slowest 5%
- Last check
- Failed
- 2 h ago, next in 4 h
Reliability
Latest check failed 2 h ago: Timed out
Status and outage history · Atom feed · Watch with other listings
How to call it
GET https://api.magentlab.com/api/calc/mipss70
Each call costs $0.005 in USDC on Base, paid with the request over x402.
Run a free test callOne unpaid request, the way an agent sends it. You see the payment challenge it gets back. Nothing is charged.
Example request
From the listing.
GET https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200Parameters
| Parameter | Type | Required | Description |
|---|---|---|---|
blasts_percent | number | Yes | Circulating blasts as a percent (0-30). ≥2 scores 1 (Guglielmelli 2018). 2.0 scores; 1.9 is the <2 arm and scores 0. magent does not read a smear. |
calr_type1_like | boolean | Yes | Presence of a type 1/like CALR mutation as assigned by the caller (Guglielmelli 2018). false (absence) scores 1. true scores 0. magent does not sequence. |
constitutional_symptoms | boolean | Yes | Constitutional symptoms as assigned by the caller (Guglielmelli 2018). true scores 1. magent does not take a history. |
fibrosis_grade | integer | Yes | WHO bone-marrow fibrosis grade as an integer 0-3, assigned by the caller (Guglielmelli 2018). ≥2 scores 1. Grade 2 scores; grade 1 scores 0. magent does not grade marrow. |
hemoglobin_g_dl | number | No | Hemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Guglielmelli 2018). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin. |
hemoglobin_g_l | number | No | Hemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the ≥100 arm and scores 0. |
hmr_mutation_count | integer | Yes | Count of high-molecular-risk mutations among ASXL1, EZH2, SRSF2, IDH1, and IDH2 as assigned by the caller (integer 0-5). ≥1 scores 1 (HMR category). ≥2 scores an additional 2 (two or more HMR mutations), so a count of 2 or more contributes 3. Count 0 scores 0. magent does not sequence. |
leukocytes_10e9_l | number | Yes | Leukocyte count in 10^9/L (0.5-200). >25 scores 2 (Guglielmelli 2018). 25.0 is the ≤25 arm and scores 0. magent does not assay leukocytes. |
platelets_10e9_l | number | Yes | Platelet count in 10^9/L (1-2000). <100 scores 2 (Guglielmelli 2018). 100.0 is the ≥100 arm and scores 0. magent does not assay platelets. |
Example response
The provider's example. We can't check it without paying.
Example response, 80 lines
{
"blasts_percent": 0,
"calr_type1_like": true,
"citation": {
"authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
"doi": "10.1200/JCO.2017.76.4886",
"id": "guglielmelli-2018",
"pmid": "29226763",
"source": "J Clin Oncol. 2018;36(4):310-318",
"title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
},
"components": [
{
"factor": "hemoglobin_lt_10",
"points": 0,
"present": false,
"value": 12
},
{
"factor": "leukocytes_gt_25",
"points": 0,
"present": false,
"value": 10
},
{
"factor": "platelets_lt_100",
"points": 0,
"present": false,
"value": 200
},
{
"factor": "blasts_ge_2",
"points": 0,
"present": false,
"value": 0
},
{
"factor": "fibrosis_ge_2",
"points": 0,
"present": false,
"value": 1
},
{
"factor": "constitutional_symptoms",
"points": 0,
"present": false
},
{
"factor": "absence_of_calr_type1_like",
"points": 0,
"present": false
},
{
"factor": "hmr_category",
"points": 0,
"present": false,
"value": 0
},
{
"factor": "hmr_two_or_more",
"points": 0,
"present": false,
"value": 0
}
],
"constitutional_symptoms": false,
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"fibrosis_grade": 1,
"five_year_survival_percent": 95,
"formula": "mipss70",
"formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
"hemoglobin_g_dl": 12,
"hmr_mutation_count": 0,
"leukocytes_10e9_l": 10,
"max_score": 12,
"median_survival_years": 27.7,
"platelets_10e9_l": 200,
"risk_band": "low",
"score": 0
}Call it from code
The curl command shows the payment challenge. The JavaScript and Python versions pay and call, and never pay more than $0.005.
curl: see the payment challenge
# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200'
# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200' \
| grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decodeJavaScript: pay and call
// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";
// Pays at most $0.005 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.005" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);
// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.005 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fapi.magentlab.com%2Fapi%2Fcalc%2Fmipss70
const res = await pay("https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200");
console.log(res.status, await res.text());Python: pay and call
# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client
# Pays at most $0.005 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.005"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))
with x402_requests(client) as session:
res = session.get("https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200")
print(res.status_code, res.text)Security scan
No findings
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Recent checks
| When | Result | HTTP | Time | Price |
|---|---|---|---|---|
| 2 h ago | Timed out | - | - | - |
| 13 h ago | Passed | 402 | 149 ms | $0.005 |
| 23 h ago | Passed | 402 | 262 ms | $0.005 |
| 33 h ago | Passed | 402 | 145 ms | $0.005 |
| 43 h ago | Passed | 402 | 344 ms | $0.005 |
Show 8 older checks
| 2 days ago | Passed | 402 | 142 ms | $0.005 |
| 3 days ago | Passed | 402 | 141 ms | $0.005 |
| 3 days ago | Passed | 402 | 261 ms | $0.005 |
| 3 days ago | Passed | 402 | 519 ms | $0.005 |
| 4 days ago | Passed | 402 | 517 ms | $0.005 |
| 4 days ago | Passed | 402 | 142 ms | $0.005 |
| 5 days ago | Passed | 402 | 140 ms | $0.005 |
| 5 days ago | Passed | 402 | 146 ms | $0.005 |