73trust / 100

Calc Mipss70

by magent in Other

x402 APIFailing, checked 2 h ago

Guglielmelli 2018 MIPSS70 for transplant-age PMF: Hb <10 g/dL (1), leukocytes >25×10^9/L (2), platelets <100×10^9/L (2), blasts ≥2% (1), fibrosis ≥2 (1), symptoms (1), no type 1/like CALR (1), HMR category (1), ≥2 HMR (2); max 12. Low 0–1, intermediate 2–4, high ≥5. Italian-cohort median (5-year) OS 27.7 y (95%), 7.1 y (70%), 2.3 y (29%). Not MIPSS70-plus or version 2.0. magent does not sequence or grade marrow.

GET
https://api.magentlab.com/api/calc/mipss70
Price
$0.005
per call in USDC
Uptime
92.3%
last 30 days
Response time
146 ms
519 ms slowest 5%
Last check
Failed
2 h ago, next in 4 h

Run a free test callHow to call it

Reliability

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Latest check failed 2 h ago: Timed out

Status and outage history · Atom feed · Watch with other listings

How to call it

GET https://api.magentlab.com/api/calc/mipss70

Each call costs $0.005 in USDC on Base, paid with the request over x402.

Run a free test callOne unpaid request, the way an agent sends it. You see the payment challenge it gets back. Nothing is charged.

Example request

From the listing.

GET https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200

Parameters

ParameterTypeRequiredDescription
blasts_percentnumberYesCirculating blasts as a percent (0-30). ≥2 scores 1 (Guglielmelli 2018). 2.0 scores; 1.9 is the <2 arm and scores 0. magent does not read a smear.
calr_type1_likebooleanYesPresence of a type 1/like CALR mutation as assigned by the caller (Guglielmelli 2018). false (absence) scores 1. true scores 0. magent does not sequence.
constitutional_symptomsbooleanYesConstitutional symptoms as assigned by the caller (Guglielmelli 2018). true scores 1. magent does not take a history.
fibrosis_gradeintegerYesWHO bone-marrow fibrosis grade as an integer 0-3, assigned by the caller (Guglielmelli 2018). ≥2 scores 1. Grade 2 scores; grade 1 scores 0. magent does not grade marrow.
hemoglobin_g_dlnumberNoHemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Guglielmelli 2018). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin.
hemoglobin_g_lnumberNoHemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the ≥100 arm and scores 0.
hmr_mutation_countintegerYesCount of high-molecular-risk mutations among ASXL1, EZH2, SRSF2, IDH1, and IDH2 as assigned by the caller (integer 0-5). ≥1 scores 1 (HMR category). ≥2 scores an additional 2 (two or more HMR mutations), so a count of 2 or more contributes 3. Count 0 scores 0. magent does not sequence.
leukocytes_10e9_lnumberYesLeukocyte count in 10^9/L (0.5-200). >25 scores 2 (Guglielmelli 2018). 25.0 is the ≤25 arm and scores 0. magent does not assay leukocytes.
platelets_10e9_lnumberYesPlatelet count in 10^9/L (1-2000). <100 scores 2 (Guglielmelli 2018). 100.0 is the ≥100 arm and scores 0. magent does not assay platelets.

Example response

The provider's example. We can't check it without paying.

Example response, 80 lines
{
  "blasts_percent": 0,
  "calr_type1_like": true,
  "citation": {
    "authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
    "doi": "10.1200/JCO.2017.76.4886",
    "id": "guglielmelli-2018",
    "pmid": "29226763",
    "source": "J Clin Oncol. 2018;36(4):310-318",
    "title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
  },
  "components": [
    {
      "factor": "hemoglobin_lt_10",
      "points": 0,
      "present": false,
      "value": 12
    },
    {
      "factor": "leukocytes_gt_25",
      "points": 0,
      "present": false,
      "value": 10
    },
    {
      "factor": "platelets_lt_100",
      "points": 0,
      "present": false,
      "value": 200
    },
    {
      "factor": "blasts_ge_2",
      "points": 0,
      "present": false,
      "value": 0
    },
    {
      "factor": "fibrosis_ge_2",
      "points": 0,
      "present": false,
      "value": 1
    },
    {
      "factor": "constitutional_symptoms",
      "points": 0,
      "present": false
    },
    {
      "factor": "absence_of_calr_type1_like",
      "points": 0,
      "present": false
    },
    {
      "factor": "hmr_category",
      "points": 0,
      "present": false,
      "value": 0
    },
    {
      "factor": "hmr_two_or_more",
      "points": 0,
      "present": false,
      "value": 0
    }
  ],
  "constitutional_symptoms": false,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "fibrosis_grade": 1,
  "five_year_survival_percent": 95,
  "formula": "mipss70",
  "formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
  "hemoglobin_g_dl": 12,
  "hmr_mutation_count": 0,
  "leukocytes_10e9_l": 10,
  "max_score": 12,
  "median_survival_years": 27.7,
  "platelets_10e9_l": 200,
  "risk_band": "low",
  "score": 0
}

Call it from code

The curl command shows the payment challenge. The JavaScript and Python versions pay and call, and never pay more than $0.005.

curl: see the payment challenge
# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200'

# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200' \
  | grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decode
JavaScript: pay and call
// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";

// Pays at most $0.005 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.005" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);

// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.005 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fapi.magentlab.com%2Fapi%2Fcalc%2Fmipss70
const res = await pay("https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200");
console.log(res.status, await res.text());
Python: pay and call
# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client

# Pays at most $0.005 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.005"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))

with x402_requests(client) as session:
    res = session.get("https://api.magentlab.com/api/calc/mipss70?blasts_percent=0&calr_type1_like=true&constitutional_symptoms=false&fibrosis_grade=1&hemoglobin_g_dl=12&hemoglobin_g_l=120&hmr_mutation_count=0&leukocytes_10e9_l=10&platelets_10e9_l=200")
    print(res.status_code, res.text)

Security scan

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