Clinical Approval Outlook

{
  "approval_candidates": [
    {
      "approval_probability": 85,
      "drug": "Lecanemab (Leqembi)",
      "ema_status": "CHMP assessment ongoing 2025",
      "fda_status": "Full approval received 2023; expanded label applications pending",
      "key_risk": "ARIA (amyloid-related imaging abnormalities) safety profile limiting real-world use",
      "mechanism": "Anti-amyloid monoclonal antibody (protofibrils)",
      "nctId": "NCT03887455",
      "sponsor": "Eisai / Biogen",
      "trial_result": "Positive — 27% slowing of clinical decline vs placebo (p<0.001)"
    }
  ],
  "approval_rate_context": {
    "disease_area_historical_phase3_success_pct": 55,
    "rare_disease_premium": "Breakthrough therapy designation adds ~15% probability uplift",
    "us_approval_rate_phase3_pct": 58
  },
  "market_context": "Alzheimer's is the highest-value CNS approval category. Any successful amyloid or tau therapy represents $5-15B peak sales potential.",
  "pdufa_calendar": [
    {
      "drug": "Donanemab",
      "indication": "Early symptomatic AD",
      "pdufa_date": "2025-Q2",
      "priority_review": true,
      "sponsor": "Eli Lilly"
    }
  ],
  "query_summary": {
    "agencies": [
      "FDA",
      "EMA"
    ],
    "condition": "Alzheimer Disease",
    "horizon": "18m"
  }
}

# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://clinicalintelpulse.theaslangroupllc.com/api/clinical/approval-outlook?agency=FDA+%7C+EMA+%7C+both+%28default%3A+both%29&condition=Disease+area+%E2%80%94+e.g.+%22Alzheimer+Disease%22+%7C+%22Multiple+Myeloma%22+%7C+%22NASH%22+%7C+%22Heart+Failure%22+%7C+%22Obesity%22&horizon=12m+%7C+18m+%7C+24m+%28default%3A+18m%29&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29'

# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://clinicalintelpulse.theaslangroupllc.com/api/clinical/approval-outlook?agency=FDA+%7C+EMA+%7C+both+%28default%3A+both%29&condition=Disease+area+%E2%80%94+e.g.+%22Alzheimer+Disease%22+%7C+%22Multiple+Myeloma%22+%7C+%22NASH%22+%7C+%22Heart+Failure%22+%7C+%22Obesity%22&horizon=12m+%7C+18m+%7C+24m+%28default%3A+18m%29&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29' \
  | grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decode

// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";

// Pays at most $0.25 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.25" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);

// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.25 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fclinicalintelpulse.theaslangroupllc.com%2Fapi%2Fclinical%2Fapproval-outlook
const res = await pay("https://clinicalintelpulse.theaslangroupllc.com/api/clinical/approval-outlook?agency=FDA+%7C+EMA+%7C+both+%28default%3A+both%29&condition=Disease+area+%E2%80%94+e.g.+%22Alzheimer+Disease%22+%7C+%22Multiple+Myeloma%22+%7C+%22NASH%22+%7C+%22Heart+Failure%22+%7C+%22Obesity%22&horizon=12m+%7C+18m+%7C+24m+%28default%3A+18m%29&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29");
console.log(res.status, await res.text());

# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client

# Pays at most $0.25 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.25"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))

with x402_requests(client) as session:
    res = session.get("https://clinicalintelpulse.theaslangroupllc.com/api/clinical/approval-outlook?agency=FDA+%7C+EMA+%7C+both+%28default%3A+both%29&condition=Disease+area+%E2%80%94+e.g.+%22Alzheimer+Disease%22+%7C+%22Multiple+Myeloma%22+%7C+%22NASH%22+%7C+%22Heart+Failure%22+%7C+%22Obesity%22&horizon=12m+%7C+18m+%7C+24m+%28default%3A+18m%29&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29")
    print(res.status_code, res.text)