Clinical Pipeline Scan

{
  "approved_drugs_context": "NSCLC has 30+ FDA-approved agents. Pipeline is additive rather than disruptive in most cases.",
  "geographic_distribution": {
    "asia_pct": 22,
    "europe_pct": 28,
    "most_active_countries": [
      "United States",
      "China",
      "Germany",
      "South Korea",
      "Japan"
    ],
    "other_pct": 5,
    "us_trials_pct": 45
  },
  "mechanism_breakdown": {
    "adc": 18,
    "bispecific": 12,
    "chemo_combinations": 31,
    "io_checkpoint_inhibitors": 62,
    "other": 81,
    "targeted_therapy": 41
  },
  "phase3_highlights": [
    {
      "countries": [
        "United States",
        "Germany",
        "Japan",
        "South Korea"
      ],
      "nctId": "NCT05116748",
      "primaryCompletion": "2026-03",
      "sponsor": "Merck",
      "status": "RECRUITING",
      "title": "Pembrolizumab + Carboplatin vs SOC in NSCLC"
    }
  ],
  "pipeline_assessment": "Extremely crowded pipeline — PD-1/L1 space saturated. ADCs and bispecifics represent highest differentiation potential. KRAS G12C targeted therapies emerging as new standard.",
  "pipeline_totals": {
    "phase2_count": 156,
    "phase3_count": 89,
    "total_active": 245
  },
  "query_summary": {
    "condition": "Non-Small Cell Lung Cancer",
    "phases_searched": [
      "PHASE2",
      "PHASE3"
    ],
    "status_filter": "RECRUITING,ACTIVE_NOT_RECRUITING"
  },
  "sponsor_landscape": {
    "academic_sponsors": "ECOG-ACRIN, Alliance, NCI leading academic cooperative groups",
    "emerging_biotechs": [
      "Turning Point Therapeutics",
      "Blueprint Medicines",
      "Mirati Therapeutics"
    ],
    "top_industry_sponsors": [
      "Roche/Genentech (18 trials)",
      "Bristol-Myers Squibb (14)",
      "AstraZeneca (13)",
      "Merck (12)",
      "Pfizer (11)"
    ]
  }
}

# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://clinicalintelpulse.theaslangroupllc.com/api/clinical/pipeline-scan?condition=Disease+or+condition+%E2%80%94+e.g.+%22Non-Small+Cell+Lung+Cancer%22+%7C+%22Alzheimer+Disease%22+%7C+%22Type+2+Diabetes%22+%7C+%22Crohn+Disease%22+%7C+%22Multiple+Myeloma%22&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29&phase=phase2+%7C+phase3+%7C+both+%28default%3A+both%29&status=active+%7C+all+%28default%3A+active+%E2%80%94+recruiting+%2B+active+not+recruiting%29'

# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://clinicalintelpulse.theaslangroupllc.com/api/clinical/pipeline-scan?condition=Disease+or+condition+%E2%80%94+e.g.+%22Non-Small+Cell+Lung+Cancer%22+%7C+%22Alzheimer+Disease%22+%7C+%22Type+2+Diabetes%22+%7C+%22Crohn+Disease%22+%7C+%22Multiple+Myeloma%22&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29&phase=phase2+%7C+phase3+%7C+both+%28default%3A+both%29&status=active+%7C+all+%28default%3A+active+%E2%80%94+recruiting+%2B+active+not+recruiting%29' \
  | grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decode

// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";

// Pays at most $0.15 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.15" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);

// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.15 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fclinicalintelpulse.theaslangroupllc.com%2Fapi%2Fclinical%2Fpipeline-scan
const res = await pay("https://clinicalintelpulse.theaslangroupllc.com/api/clinical/pipeline-scan?condition=Disease+or+condition+%E2%80%94+e.g.+%22Non-Small+Cell+Lung+Cancer%22+%7C+%22Alzheimer+Disease%22+%7C+%22Type+2+Diabetes%22+%7C+%22Crohn+Disease%22+%7C+%22Multiple+Myeloma%22&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29&phase=phase2+%7C+phase3+%7C+both+%28default%3A+both%29&status=active+%7C+all+%28default%3A+active+%E2%80%94+recruiting+%2B+active+not+recruiting%29");
console.log(res.status, await res.text());

# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client

# Pays at most $0.15 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.15"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))

with x402_requests(client) as session:
    res = session.get("https://clinicalintelpulse.theaslangroupllc.com/api/clinical/pipeline-scan?condition=Disease+or+condition+%E2%80%94+e.g.+%22Non-Small+Cell+Lung+Cancer%22+%7C+%22Alzheimer+Disease%22+%7C+%22Type+2+Diabetes%22+%7C+%22Crohn+Disease%22+%7C+%22Multiple+Myeloma%22&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29&phase=phase2+%7C+phase3+%7C+both+%28default%3A+both%29&status=active+%7C+all+%28default%3A+active+%E2%80%94+recruiting+%2B+active+not+recruiting%29")
    print(res.status_code, res.text)