Clinical Trial Brief

{
  "design": {
    "allocation": "Randomized",
    "arms": [
      "Tiragolumab + Atezolizumab + Carboplatin/Paclitaxel",
      "Placebo + Atezolizumab + Carboplatin/Paclitaxel"
    ],
    "masking": "Double-Blind",
    "primary_purpose": "Treatment",
    "study_type": "INTERVENTIONAL"
  },
  "endpoints": {
    "primary": [
      "Progression-Free Survival (PFS)",
      "Overall Survival (OS)"
    ],
    "secondary": [
      "Objective Response Rate",
      "Duration of Response",
      "Safety/Tolerability"
    ]
  },
  "enrollment": {
    "actual": 534,
    "countries": [
      "United States",
      "Spain",
      "Germany",
      "Japan",
      "Australia"
    ],
    "planned": 534
  },
  "interventions": [
    {
      "name": "Tiragolumab",
      "role": "Anti-TIGIT immune checkpoint inhibitor",
      "type": "DRUG"
    }
  ],
  "outcome_summary": "SKYSCRAPER-01 failed to meet primary PFS endpoint (HR 0.93). Significant negative readout for anti-TIGIT in NSCLC.",
  "query_summary": {
    "nct_id": "NCT04368728",
    "retrieved_from": "ClinicalTrials.gov v2 API"
  },
  "regulatory_implications": "Setback for Roche tiragolumab program. Broader TIGIT class facing headwinds.",
  "trial_identity": {
    "phase": "PHASE3",
    "primary_completion": "2022-12",
    "sponsor": "Hoffmann-La Roche",
    "start_date": "2019-06",
    "status": "COMPLETED",
    "title": "A Study of Tiragolumab in Combination With Atezolizumab and Chemotherapy Versus Placebo in Untreated Locally Advanced Unresectable or Metastatic NSCLC (SKYSCRAPER-01)"
  }
}

# bash or zsh: see the payment challenge. Nothing is charged.
curl -sS -g -i 'https://clinicalintelpulse.theaslangroupllc.com/api/clinical/trial-brief?lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29&nct_id=NCT+identifier+%E2%80%94+e.g.+%22NCT04368728%22+%7C+%22NCT05116748%22+%7C+%22NCT04815993%22'

# x402 v2 sends the challenge base64-encoded in the PAYMENT-REQUIRED header (v1 sends it in the body).
# To read the header:
curl -sS -g -o /dev/null -D - 'https://clinicalintelpulse.theaslangroupllc.com/api/clinical/trial-brief?lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29&nct_id=NCT+identifier+%E2%80%94+e.g.+%22NCT04368728%22+%7C+%22NCT05116748%22+%7C+%22NCT04815993%22' \
  | grep -i '^payment-required:' | cut -d' ' -f2 | tr -d '\r' | base64 --decode

// npm i @x402/fetch @x402/evm viem
import { wrapFetchWithPayment, x402Client } from "@x402/fetch";
import { registerExactEvmScheme } from "@x402/evm/exact/client";
import { privateKeyToAccount } from "viem/accounts";

// Pays at most $0.1 per call.
const client = new x402Client().setSpendControls({ maxAmountPerPayment: "$0.1" });
registerExactEvmScheme(client, { signer: privateKeyToAccount(process.env.EVM_PRIVATE_KEY) });
const pay = wrapFetchWithPayment(fetch, client);

// Not sure it's safe to pay? ToolVet checks it first for $0.005. Pay for that from a separate
// client: this one is capped at $0.1 per payment. GET https://toolvet.app/api/v1/check?url=https%3A%2F%2Fclinicalintelpulse.theaslangroupllc.com%2Fapi%2Fclinical%2Ftrial-brief
const res = await pay("https://clinicalintelpulse.theaslangroupllc.com/api/clinical/trial-brief?lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29&nct_id=NCT+identifier+%E2%80%94+e.g.+%22NCT04368728%22+%7C+%22NCT05116748%22+%7C+%22NCT04815993%22");
console.log(res.status, await res.text());

# pip install "x402[requests,evm]"
import os
from eth_account import Account
from x402 import x402ClientSync
from x402.http.clients import x402_requests
from x402.mechanisms.evm import EthAccountSigner
from x402.mechanisms.evm.exact.register import register_exact_evm_client

# Pays at most $0.1 per call.
client = x402ClientSync().set_spend_controls({"max_amount_per_payment": "$0.1"})
register_exact_evm_client(client, EthAccountSigner(Account.from_key(os.environ["EVM_PRIVATE_KEY"])))

with x402_requests(client) as session:
    res = session.get("https://clinicalintelpulse.theaslangroupllc.com/api/clinical/trial-brief?lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29&nct_id=NCT+identifier+%E2%80%94+e.g.+%22NCT04368728%22+%7C+%22NCT05116748%22+%7C+%22NCT04815993%22")
    print(res.status_code, res.text)