ivive.app

Reliability

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How to connect

Add it to any MCP client that supports remote servers.

{
  "mcpServers": {
    "ivive-app": {
      "type": "http",
      "url": "https://api.ivive.app/mcp/"
    }
  }
}

6 tools

• predict_inputs

  Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict.

• calc_clhep

  Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs.

• target_clint

  The in-vitro CLint an assay must read for a compound to reach a target plasma clearance.

• input_sensitivity

  How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.

• similar_drugs

  Most similar reference drugs to a SMILES, with observed and IVIVE-predicted clearance: how IVIVE fared on this kind of structure.

• scale_to_human

  Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted.

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