Pharmacogenomics Guidelines MCP Server

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How to connect

Add it to any MCP client that supports remote servers.

{
  "mcpServers": {
    "pharmacogenomics-guidelines-mcp-server": {
      "type": "http",
      "url": "https://pharmacogenomics-guidelines.caseyjhand.com/mcp"
    }
  }
}

6 tools

• pgx_search_pairs

  Search evaluated gene–drug pairs by gene, literal drug-name substring, exact drug/RxNorm/ATC identifiers, evaluation level or testing label. Filters combine with AND; identifiers never fall back to name-only search. Results include source drug identifiers and guideline links for…

• pgx_get_guideline

  Retrieve guideline coverage by source ID, exact gene symbol or exact drug name/ID. Default summary pages complete guideline records with exact drugCount/pairCount. view=drugs or pairs requires by=id and pages only that related collection, retaining its guideline descriptor…

• pgx_lookup_diplotype

  Translate a CPIC-supported diplotype or allele-status result for one gene. Supply geneSymbol and exact diplotype notation, including star alleles, named HLA positive/negative statuses, or non-star sequences; use pgx_search_alleles and pgx_list_reference with topic phenotypes to…

• pgx_get_recommendations

  Browse CPIC recommendations in drug mode with one exact drugName or drugId. Match across drugs in results mode with geneResults or geneSymbol plus phenotype/activityScore, or genotype mode with 1–10 uniquely resolved gene/diplotype entries. Both matching modes accept an optional…

• pgx_search_alleles

  Inspect CPIC allele function, evidence, definition metadata and complete population frequencies for geneSymbol. Name matches literally first, then a matching gene prefix before a star allele may be removed; clinicalFunctionalStatus matches literal text case-insensitively…

• pgx_list_reference

  Inspect gene symbols, gene-specific source results, CPIC levels, ClinPGx testing labels, recommendation classifications and input formats. phenotypes requires geneSymbol and preserves distinct activity-score rows, frequencies and consultation text. Live genes/phenotypes support…

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